Progressive adipocyte hypertrophy
WebMay 22, 2006 · Mice deficient in AQP3 have dry skin, reduced skin elasticity and impaired epidermal biosynthesis. Mice lacking AQP7 manifest progressive adipocyte fat accumulation and hypertrophy. These skin and fat phenotypes are attributable to impaired glycerol transport. WebIn obesity, adipocyte hypertrophy and proinflammatory responses are closely associated with the development of insulin resistance in adipose tissue. However, it is largely unknown whether adipocyte hypertrophy per se might be sufficient to provoke insulin resistance in obese adipose tissue.
Progressive adipocyte hypertrophy
Did you know?
WebMar 27, 2009 · Author summary Obesity is an enlargement of adipose tissue to store excess energy intake. Hyperplasia (cell number increase) and hypertrophy (cell size increase) are two possible growth mechanisms. The in vivo dynamic change of fat tissue cannot be monitored in real time due to current technical limitations. However, we can measure cell … WebOct 6, 2024 · Specific mechanisms of adipocyte hypertrophy include dysregulated differentiation and maturation of preadipocytes, enlargement of lipid droplets, and …
WebJan 19, 2024 · Enlarged adipocytes are usually related to metabolic dysfunction, whereas small adipocytes are associated with metabolic benefits 15, 16, 20; however, paradoxical data have been reported in... WebApr 22, 2005 · In contrast, at age 4 weeks, adipocyte volume and body fat mass were comparable in wild type and AQP7 null mice. To investigate the mechanism(s) …
For CLS induction, we used an established tissue culture model19. After sacrifice, the rostral part of the epididymal white adipose tissue (EWAT) was dissected and cut into small pieces of <1 mm³ (AT explants) under sterile conditions at 37 °C in PBS. AT explants were then transferred to six-well plates filled with 1 ml … See more Animal experiments followed the ‘Principles of laboratory animal care’ (NIH publication no. 85e23, revised 1985) as well as specific national laws approved by the … See more Live-imaging was performed on AT explants of HFD-fed MacGreen mice stained with 1 µg/ml BODIPY 558/568 C12 (Life Technologies GmbH, Darmstadt, Germany) … See more Laser-injury of individual adipocytes was performed on AT explants of chow-fed mice without pre-established AT inflammation. After the 72 h of cultivation, … See more Antibody staining was performed on AT whole mounts and AT explants after live-imaging. Of note, AT explants were immobilized on the cell culture inserts by adding … See more WebNational Center for Biotechnology Information
WebOct 20, 2024 · Adipogenesis is the process by which adipocytes develop from adipose-derived stem cells to form the adipose tissue. ... The excess fat mass can be the result of both hypertrophy (increase in cell size) and hyperplasia (increase in ... Human pathologies like progressive osseous heteroplasia, in which ectopic bone arises from the …
WebOct 1, 2024 · As a primary fat and triacylglycerol depot, AT has the plasticity to adjust to a surplus in energy through progressive adipocyte hypertrophy as well as proliferation and differentiation of pre ... sublimation printers at best buyWebSep 1, 2024 · Histologic evaluation of the adipose tissue showed increased intercellular fibrosis and adipocyte hypertrophy. Serum analysis showed an aberrant lipid metabolism without changes in the circulating adipokines. In an adipogenesis gene array, a distinct gene expression profile associated with macrophages was observed. painkillers in pregnancy first trimesterWebSep 4, 2024 · Adipocytes undergo pronounced changes in size and behavior to support diverse tissue functions, but the mechanisms that control these changes are not well understood. Mammary gland-associated ... sublimation printers financingWebProgressive Adipocyte Hypertrophy in Aquaporin-7-deficient Mice ADIPOCYTE GLYCEROL PERMEABILITY AS A NOVEL REGULATOR OF FAT ACCUMULATION* Received for publication, January 21, 2005, sublimation printers for heat transfer 11x14WebFeb 25, 2016 · Adipocyte hypertrophy is a recognized feature of dysfunctional adipose tissue that is associated with increased cellular stress, decreased metabolic flexibility, and systemic diabetes. The mechanisms that regulate hypertrophy are unclear. In this study, we identify two potential features of DM patients that may contribute to increased adipocyte ... painkillers in pregnancyWebJul 5, 2024 · This study evaluates the progressive participation of enzymes involved in lipolysis and lipogenesis, leading to adipocyte hypertrophy in a metabolic syndrome (MS) rat model caused by chronic... sublimation printer sawgrass 1000WebMar 22, 2024 · Adipocyte hypertrophy and hypoxia are crucially involved in adipose tissue inflammation via induction of pro-inflammatory cytokines, as well as of chemokines that … sublimation printers office depot