WebJun 11, 2024 · We demonstrate that in cMYC-driven B cell lymphoma in mouse models, MYSM1-loss represses ribosomal protein gene expression and protein synthesis. Importantly, the loss of MYSM1 also strongly... WebJan 7, 2024 · MYSM1 is primarily a nuclear chromatin binding protein and comprises the …
(PDF) Genetic and Pharmacological Inhibition of Astrocytic Mysm1 …
WebOct 27, 2024 · MYSM1 served as a CRC suppressor by inducing apoptosis and inhibiting cell proliferation, EMT, tumorigenic potential and metastasis. Mechanistically, MYSM1 directly bound to the promoter region of miR-200/CDH1, impaired the enrichment of repressive … WebJun 11, 2024 · Overall, we demonstrate that the loss of MYSM1 in mouse B cell lymphoma represses the induction of ribosomal protein genes, reduces cellular protein synthesis rate, promotes p53 activation and potently inhibits cMYC oncogenic functions. townhouses for sale in mays landing nj
Repression of p53-target gene Bbc3/PUMA by MYSM1 is essential …
WebNov 22, 2024 · In this study, it is observed that deubiquitinase Mysm1 is induced in the brain tissues from patients with major depression and from mice with depressive behaviors. The genetic silencing of... WebMay 12, 2024 · In the present study, we knocked down MYSM1 expression by transfecting … WebJun 9, 2016 · Mysm1−/− mice have severely decreased cellularity in hematopoietic organs. We previously revealed that Mysm1 knockout impairs self-renewal and lineage reconstitution of HSCs by abolishing the ... townhouses for sale in mccalla al