Fractionation sensitivity
http://irochouston.mdanderson.org/RPC/CREDENTIALING/files/0415.pdf WebThe dependence of the iso-effective radiation dose on the dose per fraction. Usually quantified by the α/β ratio – a high fractionation sensitivity is characterised by a low α/β …
Fractionation sensitivity
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WebJun 20, 2016 · In 1999, Brenner and Hall claimed that the fractionation sensitivity of prostate cancer was such that “appropriately designed hypofractionation schemes would be expected to maintain current levels of tumor control and late sequelae…with the logistical and financial advantages of fewer numbers of fractions”. ... WebAug 11, 2024 · Yarnold J, Ashton A, Bliss J, et al: Fractionation sensitivity and dose response of late adverse effects in the breast after radiotherapy for early breast cancer: Long-term results of a randomised trial. …
WebAug 2, 2024 · These cells are then more sensitive to subsequent doses of radiation. Repair. Fractionation increases the destructive effect on tumor cells while minimizing damage … WebMar 19, 2024 · The two test dose regimens in START-P were 13-fraction regimens estimated to be isoeffective with 50 Gy in 25 fractions based on α/β-values of 6 and 3 Gy respectively, representing the highest and lowest estimates of fractionation sensitivity of the dose-limiting late-reacting normal tissues of the breast/ribcage consistent with the ...
WebJun 21, 2015 · Change in the expression of epidermal growth factor receptor (EGFR) genes can also give some hints regarding the fractionation sensitivity (Somaiah et al. 2015), which can also be measured mid ... WebJul 10, 2015 · The fractionation sensitivity of any tissue is characterized by its α/β value; the α/β value is a mathematically calculated term derived from the dose-effect curve of the tissue, given in units of Gray (Gy). Generally, the α/β values of healthy tissues for late reactions are low (in the range of 2-3 Gy). ...
WebApr 8, 2024 · Collateral sensitivity (CS), whereby resistance to one drug is accompanied by increased sensitivity to another, provides new opportunities for antimicrobial drug discovery. Here, Liu et al. screen ...
WebDec 4, 2024 · The relative weighting of each component, and thus the sensitivity to fractionation of the irradiated tissue, is characterized by a parameter called the alpha-beta ratio. ... Over the past 2 years, several large randomized controlled trials comparing conventional fractionation (1.8 to 2 Gy per fraction) with moderate hypofractionation … brofx 1-10WebMar 15, 2024 · Purpose: Randomized trials of altered dose/fractionation for external beam radiation therapy are meta-analyzed with the aim of establishing the dose response and fractionation sensitivity. Methods and materials: Studies were identified through PubMed through April 1, 2024. Studies of any-risk prostate cancer patients and any modification … brofx 07WebAn estimate of 4 Gy for α/β value has been already reported for the fractionation sensitivity of breast cancer . The low estimated α/β ratio for breast cancer means that it is probably as sensitive to fraction size as is dose-limiting normal tissue, and hypofractionation for breast cancers may actually be advantageous. ... car chania hireWebper fraction and the fractionation sensitivity of the tissue. Two asymptotic properties are also clear: lim d r 0 g N 2 g d (5) and lim d r 00 g N g d (6) Equation 6 is intuitively clear: tissues with a/b / / d r will exhibit low fractionation sensitivity, and it is the fractionation effect that causes the double trouble phenomenon. car changing colourWebMar 15, 2024 · Breast and prostate cancers may generally have a lower alpha-beta ratio than the head and neck squamous cell carcinomas that were evaluated to derive an initial understanding of sensitivity to dose fractionation. 5 However, questions remain about whether the lower alpha-beta ratio is specific to hormone-sensitive subtypes, which … car changing color with remoteWebJan 1, 2001 · A trial has been undertaken to quantitate the fractionation sensitivity of breast tissues as part of a UK initiative to standardise radiotherapy practices. Methods: … brofx 14Web12 hours ago · Within rice plant, the degree of isotope fractionation in different tissues was significantly different, but the fractionation trend under different treatments was consistent. Generally, roots were preferentially enriched in light Cd than the aboveground part, with the δ 114/110 Cd value of −0.57‰ (DY), −0.47‰ (AWD), and −0.43‰ (FL ... car changing station