Cyclothialidine
WebThecyclo- thialidinesarenaturallyoccurringcyclicpeptideinhibitors (Goetschietal., 1993), ofwhichGR122222Xisamember (Figure 1), andarealso inhibitors ofthe ATPase activity of the B subunit of DNAgyrase(Nakadaetal., 1994). WebCyclothialidine is a new, potent DNA gyrase inhibitor isolated from Streptomyces filipinensis. However, it exhibits hardly any growth-inhibitory activity against intact …
Cyclothialidine
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WebJun 16, 1995 · Cyclothialidine contains a unique 12-membered lactone ring that is partly integrated into a pentapeptide chain(21). Cyclothialidine exhibited the highest … WebAbstract. The DNA gyrase inhibitor cyclothialidine was shown to be an interesting lead structure for the search of new antibacterials. During extensive work elucidating the structure-activity relations, it was demonstrated that variation of the lactone ring size of its bicyclic core was tolerated. Indeed, even ‘ seco ’ analogues exhibited ...
WebDec 6, 2024 · 优先权要求. 本申请要求于2024年9月28日提交的美国临时申请no.62/564,820；于2024年3月10日提交的美国临时申请no.62/469,989的权益。 WebCyclothialidine (1, Ro 09-1437) is a potent DNA gyrase inhibitor that was isolated from Streptomyces filipinensisNR0484 and is a member of a new family of natural products.
WebA total synthesis of cyclothialidine (1), a new DNA gyrase inhibitor isolated from Streptomyces filipinensis, is described. The synthetic concept was tested by preparing the lactone 13(Scheme 2) which contains the characteristic bicyclic core entity of 1. WebCyclothialidine (1, Ro 09-1437) is a potent DNA gyrase inhibitor that was isolated from Streptomyces filipinensisNR0484 and is a member of a new family of natural products.
WebDec 9, 2003 · Cyclothialidine (1, Ro 09-1437) is a potent DNA gyrase inhibitor that was isolated from Streptomyces filipinensis NR0484 and is a member of a new family of …
WebCyclothialidine Alternative Names: RO 091437 Latest Information Update: 18 Jul 2000. Price : $50 * Buy Profile. Adis is an information provider. We do not sell or distribute actual drugs. Final gross price and currency may vary according to local VAT and billing address. Your purchase entitles you to full access to the information contained in ... gt \u0026 associatesWebCyclothialidine C C26H35N5O11S CID 10699166 - structure, chemical names, physical and chemical properties, classification, patents, literature, biological ... finder to update iphoneWebCyclothialidine C26H35N5O12S CID 164470 - structure, chemical names, physical and chemical properties, classification, patents, literature, biological activities, safety/hazards/toxicity information, supplier lists, and … finder train the trainerWebThe mechanism of inhibition of DNA gyrase by cyclothialidine, a novel gyrase inhibitor isolated from Streptomyces filipinensis NR0484, has been studied further by using … gtt work from home jobsWebAntioxidative Antiviral Bioactive by-products Cyclosporin Analogue Set Enzyme inhibitors Mycotoxins Raw Materials of Healthcare Products Tacrolimus Analogue Set Others International : 1-631-504-6093 US & Canada (Toll free): 1-844-BOC (262)-0123 Fax: 1-631-614-7828 Email: [email protected] 45-16 Ramsey Road, Shirley, NY 11967, USA finder trout tubertiniWebCyclothialidine C C26H35N5O11S CID 10699166 - structure, chemical names, physical and chemical properties, classification, patents, literature, biological activities, … gtt wifi password changeWebOct 1, 1994 · We investigated how cyclothialidine (Ro 09-1437), a novel DNA gyrase inhibitor belonging to a new chemical class of compounds, acts to inhibit Escherichia coli DNA gyrase. Cyclothialidine up to... gt two cars