Borocaptate
WebMar 1, 2003 · The pharmacokinetics of sodium borocaptate (BSH), a drug that has been used clinically for boron neutron capture therapy (BNCT) … WebTo improve a drug delivery in BNCT, we devised transferrin-conjugated polyethylene-glycol liposome encapsulating sodium borocaptate (TF-PEG-BSH). Methods: (10)B …
Borocaptate
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WebDec 1, 2001 · Boron neutron capture therapy (BNCT) is based on a nuclear capture reaction that occurs when boron-10, a stable isotope, is irradiated with low energy neutrons to produce high-energy alpha particles and recoiling lithium-7 nuclei. The purpose of the present study was to determine what urinary metabolites, if any, could be detected in … WebSodium borocaptate (50 mg ¹⁰B/kg) was administered to tumor-bearing hamsters. Groups of 3-5 animals were killed humanely at nine time-points, 3-12 h post-administration. …
WebApr 17, 2013 · Sodium borocaptate is a very efficient carrier of 10 B, but the selectivity of tumor accumulation depends on the defective blood brain barrier (BBB) in brain tumors versus the intact BBB in normal brain (Ono et al. 2000). Within this context, its utility as a stand-alone boron agent would seem to be restricted to brain tumors. WebBorocaptate sodium B10 (also known as sodium borocaptate), a boron compound for use in boron neutron capture therapy. After parenteral administration, sodium borocaptate …
Web用于防止癌细胞转移的化合物、组合物和方法专利检索，用于防止癌细胞转移的化合物、组合物和方法属于肝细胞生物学专利检索，找专利汇即可免费查询专利，肝细胞生物学专利汇是一家知识产权数据服务商，提供专利分析，专利查询，专利检索等数据服务功能。 WebAug 22, 2024 · This work examines modulation effects of two borocaptate compounds on radiation-induced DNA damage. Aqueous solutions of pBR322 plasmid containing increasing concentrations of borocaptates were ...
WebJan 1, 2012 · Abstract. This chapter is based on a shortened version of the investigators brochures from the EORTC clinical trials 11001 and 11011 concerning the boron compounds sodium borocaptate (BSH) and boronophenylalanine (BPA). It summarizes essential information that might be asked by regulatory authorities.
Webborocaptate ( uncountable ) The anion of a mercapto- derivative of a particular caged borane; it is used as a therapeutic source of boron quotations . 2015 September 2, “The … tng woman uniformWebObjective: The purpose of this study was to obtain tumor and normal brain tissue biodistribution data and pharmacokinetic profiles for sodium borocaptate (Na2B12H11SH) (BSH), a drug that has been used clinically in Europe and Japan for boron neutron capture therapy of brain tumors. The study was performed with a group of 25 patients who had … tng windshield raleighhttp://www.ichacha.net/二硫卡钠.html tng woundedWebEach tumor-bearing rat received one of two different amounts of sodium borocaptate (BSH) and/or 500 mg/kg of boronophenylalanine (BPA) via intraperitoneal injection. We compared the boron concentrations of the tumor, the contralateral normal brain and the blood in rats of 3 different treatment groups (BSH alone, BPA alone and a combination of ... tng yesterday\u0027s enterprise castWebSodium borocaptate (Na 2 B 12 H 11 SH, designated as “BSH”) has been used clinically in Japan for over 25 years by Hatanaka et al. as a capture agent for boron neutron capture therapy (BNCT) of brain tumors. 1 Independently, p — boronophenylalanine (BPA), which originally had been synthesized by Snyder 2, has been used clinically by Mishima et al. … tng yellow uniformWebMar 1, 2003 · The pharmacokinetics of sodium borocaptate (BSH), a drug that has been used clinically for boron neutron capture therapy (BNCT) of malignant brain tumors, have been characterized by measuring ... tng worldwide beautyWebBorocaptate. For example, boron, sodium borocaptate, and boronated EGF have been utilized for boron neutron capture technology,155 and CED of liposomes encapsulating Rhenium-186 beta-emitting therapeutic radionuclides was shown to improve survival of … tng worldwide main